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Here we review and extend a new unitary model for the pathophysiology of involutional osteoporosis that identifies estrogen E as the key hormone for maintaining bone mass and E deficiency as the major cause of age-related bone loss in both sexes. Also, both E and testosterone T are key regulators of skeletal growth and maturation, and E, together with GH and IGF-I, initiate a 3- to 4-yr pubertal growth spurt that doubles skeletal mass. Although E is required for the attainment of maximal peak bone mass in both sexes, the additional action of T on stimulating periosteal apposition accounts for the larger size and thicker cortices of the adult male skeleton. Aging women undergo two phases of bone loss, whereas aging men undergo only one. In women, the menopause initiates an accelerated phase of predominantly cancellous bone loss that declines rapidly over yr to become asymptotic with a subsequent slow phase that continues indefinitely. The accelerated phase results from the loss of the direct restraining effects of E on bone turnover, an action mediated by E receptors in both osteoblasts and osteoclasts.
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Introduction: Limited information is available regarding sexual functioning among adults aged 70 years and older. Aims: To assess sexual functioning among older men and women, and ascertain patient-physician communication patterns about sexual functioning. Methods: Prospective participants were approached prior to scheduled appointments with their primary care physician. In-depth sexual histories were obtained along with data on their demographic, medical, psychological, and cognitive status. The most commonly reported sexual activity was intercourse for men and masturbation for women.
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Sex steroids and the construction and conservation of the adult skeleton

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I grew up in Australia, first in Melbourne, then Brisbane from age four, then Townsville in northern Queensland from age eight, then back to Melbourne when I was ten. I was brought up secularly. My early childhood was fine; I was an overachiever who loved dancing and gymnastics. When I reached adolescence things became more difficult because of being bullied and struggling with self-confidence, so I changed schools and that helped.
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